Structure complex of our quinoline-substituted anthracenyl isoxazole amides (Quin-AIM), the most potent of our latest AIM series, bound to the c-Myc G-quadruplex. C-Myc is an oncogene that plays a central role in development of cancer. The G-quadruplex of the c-Myc promoter region plays a role in regulating transcription and stabilization of this structure (such as with the Quin-AIM pictured here) has been shown to suppress gene-expression. These structures represent a promising target for small molecule anti-tumor agents.

This compound is currently being tested as a new therapy in brain, lung, and breast cancers.